So far, there has been no official comment from the film's stars or Sony Pictures about a potential sequel to "The 5th Wave." However, upon further investigation, the series' fate can possibly be determined.
On Rotten Tomatoes, "The 5th Wave" has a 16% critic score and a 38% audience score. The general consensus reads, "With unimpressive effects and plot points seemingly pieced together from previous dystopian YA sci-fi films, 'The 5th Wave' ends up feeling like more of a limp, derivative wriggle." "The 5th Wave" unfortunately did not seem to sit well with either critics or fans due to its reliance on tropes often found in this genre.
Furthermore, the film's box office outcome wasn't too pretty either (via Box Office Mojo). With an estimated budget of $38 million, the $34 million domestic gross wasn't even enough to break even. The overall worldwide gross, however, was just under $110 million. Both factors of critical reception and box office performance could have affected sequel potential, as touched upon by Daily Hind News.
The editor speculated, "In the face of disappointing revenues from The 5th Wave ... and the disastrous reviews, Sony Pictures decides to put an end to the exploitation of the literary saga." Although there has been no official announcement of cancellation from Sony Pictures, Daily Hind News seems to be implying that these factors led to Sony's disinterest in continuing the series.