The open-ended nature of The Return and its finale makes it feel very possible to go back. The fact of the matter, however, is that David Lynch is, as we mentioned earlier, 74 years old, and Mark Frost is 66. Given that, it certainly can't wait another 25 years, and the process of making The Return from start to finish took over four years, according to comments from Lynch during a panel he attended in Belgrave soon after the series' 2017 release. The combination of time marching on and the somewhat flaky nature of Lynch's creative cycles is the enemy of any more Twin Peaks.
Even if more episodes were to come to the fore, it's very possible that it wouldn't really be "about" Twin Peaks — the place or its citizens, that is — at all; Lynch has expressed some inscrutable amount of interest in expanding Carrie Page's story. She only appears in part 18 as the alternate-reality Laura-that-isn't-really-Laura that Cooper tries to return to Twin Peaks. Her character is from Odessa, Texas, and the only background fact we ever really learn about her is that she definitely murdered some guy and left him on her couch to rot when Cooper came by looking for her.
All of these explanations are "maybe"s and "possibly"s, but the overarching fact is that it's really unlikely to happen at all. Lynch returned to Twin Peaks on his own schedule and creative imperative, told the story he wanted to (something he couldn't truly accomplish during the show's original run), and left it for us to interpret as we will. Just like the original announcement for The Return, if anything else is going to happen, it will most likely strike like a bolt from the blue.