"Grey's Anatomy" takes places in Seattle, Washington, and the vast majority of the characters are believed to be American. In fact, only a couple of main or recurring characters have had foreign accents, and neither of them -– Dr. Cormac Hayes (Richard Flood) and Dr. Carina DeLuca (Stefania Spampinato) –- have been especially central to the show. But don't let the accents fool you, because a great number of the "Grey's Anatomy" characters are played by foreign actors. Dr. Callie Torres, for example, is portrayed by Mexican-born actor Sara Ramirez, who moved to the US at the age of eight.
"Grey's Anatomy" has also had many Canadians appear in major roles. These include Sandra Oh as Dr. Cristina Yang, Catarina Scorsone as Dr. Amelia Shepherd, Scott Speedman – born in London — as Dr. Nick Marsh, and Giacomo Gianniotti – born in Italy — as Dr. Andrew DeLuca. Three other cast members have also had to hide their accents for the show –- Camila Luddington (Dr. Jo Wilson) is British, Kevin McKidd (Dr. Owen Hunt) is Scottish, and Martin Henderson (Dr. Nathan Riggs) is from New Zealand. "'Grey's' was my first American accent role, and so, I still screw up like every single day," Luddington admitted on "Live with Kelly and Ryan" in May 2022. "Now it's been 10 years, so hopefully I'm a little bit better and, in real life, my accent is slowly becoming more American."
