One of the more consequential figures in Rick Grimes' early war with the notorious Governor is Andrea. She begins the series as one of the people Shane helps get out of Atlanta. Following the death of her sister, Andrea's main journey is one of a woman who refuses to ever be helpless again.

After the Greene farm is overrun, she goes on the road with Michonne and they make their way to Woodbury, where the Governor rules with an iron fist. Unafraid, Andrea begins a relationship with him and even finds herself among his most trusted generals.

However, she quickly realizes that she bet on the wrong horse as his madness and utter contempt for human life starts to show. She realizes that he's the villain of the story and begins taking steps to allow Rick to win, including leaving Woodbury and warning of an impending attack.

Unfortunately, the Governor personally tracks her down. Although she puts up quite a fight, his relentless mania is too much for her. He knocks her out and drags her back to his torture room in Woodbury where he orders her ally in the escape, Milton, to execute her. He refuses, prompting the Governor to kill him and allow him to reanimate alone in a room with Andrea.

She is bitten. Never wanting to be helpless again, she requests a pistol from Rick to end things on her own terms.