Season 1 of "Nine Perfect Strangers" was based on a novel, meaning Season 2 will be based on completely original material, apart from the character of Masha Dmitrichenko. In June 2023, it was reported that Nicole Kidman would once more play that role, the operator of a high-end wellness retreat facility. And while we don't yet know much about the fictional people we'll see in "Nine Perfect Strangers" Season 2, we know that they'll be brand new seekers of therapy and healing, what their names are, and which actors will be bringing them to life.

Emmy-winning "Schitt's Creek" star Annie Murphy heads up the list of strangers as Imogen, along with Christine Baranski of "The Gilded Age" as Victoria, Lucas Englander ("Transatlantic") as Martin, and in her narrative television debut, rock musician King Princess as Tina. Also joining the ensemble drama in its second season, we've got "Triangle of Sadness" co-star Dolly de Leon as Agnes, "The White Lotus" and "The Last of Us" breakout Murray Bartlett as Brian, rising Turkish star Aras Aydin as Mateo, and The CW stalwart Maisie Richardson-Sellers ("The Undeclared War") as Wolfie.