Some of the series' most skilled characters also use Nature Transformation Combinations, which are powerful attacks formed from the combination of Nature Transformations. In the Naruto manga Chapter #316, Yamato shows this technique to Naruto by detailing the breakdown of his Wood Release Jutsu. As he tells Naruto, there technically is no such thing as a Wood Nature Transformation. Instead, he uses Earth Transformation in his right hand and Water Nature Transformation in his left hand to come up with his signature Wood Release ability. As Kakashi explains in the same chapter, Yamato possesses a Kekkei Genkai, which is an anomaly in his DNA that allows him to use and combine the two Nature Transformations. Kekkei Genkai are passed down generationally throughout different clans. For example, Haku had a Kekkei Genkai that allowed him to use his Ice Style attacks in his battle against Naruto and Sasuke early in the series.

Yet there are some characters that are also able to use a combination of three Nature Transformations. This three-part combination is due to the more advanced form of Kekkei Genkai called Kekkei Tota, and the most well-known is the Dust Release technique from the Third Tsushikage, Onoki. Onoki debuts this technique in Chapter #466 against Sasuke. The Transformation combines Fire, Wind, and Earth to essentially reduce its victim into nothing but particles of dust.

Suffice to say, with the right balance and control of Nature Transformations, characters can come up with the most awesome and innovative combos.