Jessi Glaser (Jessi Klein) is another of the main characters in "Big Mouth." Intelligent and liberal, she is a friend to Andrew, Missy, and Nick and always wants to do the right thing. However, she does tend to go about it in the wrong way at times, occasionally with negative consequences. This is largely due to her being an outspoken character who is not afraid to let others know her views. She lives with her mother after both of her parents divorced, although the character initially wanted to go with her dad, causing some resentment.
A natural pessimist, Jessi regularly sees the worst in people and has a dark worldview that can make her gloomy to be around. However, she is also a great and loyal friend, sticking up for those she cares for. Jessi has struck up a strong relationship with her hormone monster, Connie, and has dealt with a lot so far in the series, leading to the occasional emotional outburst or angry rant. Jessi has arguably developed the most in "Big Mouth," with a good example being when she experiences depression as a result of her parent's divorce and starts seeing a therapist.